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An anal fissure AF is a tear in the epithelial lining of the anal canal. This is a very common condition, but the choice of treatment is unclear. The use of anal dilators is effective, economic, and safe. The aim of the study was to compare the efficacy of two conservative treatments, the use of anal dilators or a finger for anal dilatation, in reducing anal pressure and resolving anal fissures. Fifty patients with a clinical diagnosis of AF were randomly assigned to one of the treatments, self-massage of the anal sphincter group A, 25 patients or passive dilatation using dilators group B, 25 patients. All patients were evaluated at baseline, at the end of treatment, and after 12 weeks and 6 months.
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Probiotic Enemas: Fact or Fiction?

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Anal self-massage in the treatment of acute anal fissure: a randomized prospective study

Because lubricants may decrease trauma during coitus, it is hypothesized that they could aid in the prevention of HIV acquisition. The rheological properties of the lipid-based lubricants precluded testing with the exception of explant safety testing. Six aqueous-based gels were hyperosmolar, two were nearly iso-osmolar, and two were hypo-osmolar. Two nearly iso-osmolar aqueous- and both silicone-based gels were not toxic toward epithelial cell lines or ectocervical or colorectal explant tissues. While most of the lubricants had no measurable anti-HIV-1 activity, three lubricants which retained cell viability did demonstrate modest anti-HIV-1 activity in vitro. To determine if this would result in protection of mucosal tissue or conversely determine if the epithelial damage associated with the hyperosmolar lubricants increased HIV-1 infection ex vivo , ectocervical tissue was exposed to selected lubricants and then challenged with HIV
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Anal self-massage in the treatment of acute anal fissure: a randomized prospective study

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Probiotics are live microorganisms that benefit your body. The human colon is home to billions of beneficial bacteria that play an important and complex role in digestion, immune function, and other bodily processes. Having the correct number and balance of microorganisms in your colon can help to reduce inflammation, improve the absorption of nutrients, and prevent digestive issues, such as gas and bloating.
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